
IASO presents first in human multiple myeloma data from two assets
IASO Bio
2026年9月27日
At the International Myeloma Society meeting over the weekend in Glasgow, Scotland, UK IASO released its first data on two assets to treat relapsed / refractory multiple myeloma. A group of 10 patients, receiving a single infusion of IASO206 (a BCMA-targeted CAR-T cell therapy), showed a robust expansion of CAR-positive T cells, with peak between 12 and 21 days, but detectable up to six months after treatment. IASO206, administered without apheresis or lymphodepleting chemo, achieved a 90% objective response rate, increasing to 100% in the higher dose cohort. In a second data release in 9 patients, IASO announced RD140, a fully human BCMA/GPRC5D dual-targeted FasT CAR-T cell therapy, showed an 88.9% objective response rate, again hitting 100% in the higher dose cohort. RD140 was built on the FasT CAR-T platform, with cell manufacturing in 3-4 days.
